JPS118-1504182100@
* 0150418 morning
1.mesenchymal stem cell T-lymphocytes cell therapy direction to blood bone, myocardial
,vessels,etc.
.stromal cell from bone marrow has multipotency. MSC has a potency which concentrate to target organ ,with injection, also to malignant organs.
(TNF-alpha concerns that)
.Now using for GVHD therapy hemopoetic stem cell increase. Mega study OSIRIS exists,but no dominant results. Surely effective! Crisis of GVHD depends on HLA-mis match,but MSC conserns not so severe this point because of multipotency.
. MSC supress the proliferation of Th17.
.MSC has effective for Treg proliferation.
.MSC therapy for GVHD is about 3times against ordinal therapy.
.Why accumulate MSC to malignant(targetted) organs?
many cytocaines concern. Adhesiveness concern. TNF-alpha concern.
2 Chimeric Antigen Receptor CAR
.CD-19 CAR for ALL ,CLL, nonHML effective
. efficacy part is different to rituximab
. Initially supress process of Treg.
.currently there are 78 INDs for gene modified T cells
.Chimera antibody is a antenna of target cell ,is combined surface of CD19 T cell.
.subeffect CRS .Akutemura is effective which not reduce severely the effecacy of MSC.
.CDCT center began. Center for Gene and Cell Therapy
3 How about pediatric activity mainly women's in Asia ?
Leaders each representing own pediatric society talk on current status and emerging trends of pediatric health care as well as the pressing issues on female pediatricians as predominating workforce and as future leaderships.
Dr. Igarashi discusses both brighter and darker sides of child health care in Japan and talk on the strategic plans for emerging health promotion needs at multiple levels as family, hospital, community and national policy.
Dr. Klein navigates us from global perspectives through ever-changing aspects of child health care leading to robust disparities, diversities, complexities and changing priorities in child health care.
Dr. Wu sheds light on the issue of the decline of the practicing pediatricians in Taiwan：maternal role during the period after the completion of pediatric residency is one of the contributing factors. She also talks on a declining workforce for pediatric inpatient care and emergency service.
In Taiwan lesional doctor must commit over-night duty in Hospital?
civil insurrance for medicine in population japan is better ,because of good industries.
Dr. Chuansumrit presents the pediatric health care systems where female pediatricians are predominant. Environment for working female pediatricians in Thailand is rather unique in that they are well supported and little gender discrimination is reported.
only 9% is pediatricial in Thailand
aabout gender disrimination muchi but lesser in medical fields
It has feelings,that in Thailand, more familily-like is the doctor's society, more communication like a family, because of high-class, lika a prince or princess.
nutrition problem more rich give child a kilo gram gall stone!
Many (most 1/3 ped. hematology) women work as professor or asistant prof.
because of regulation of government.
2-高-9
.SCID TREC BY QPCR scid has 20 causes in nowadays.
. transient TCL ( T-cell leduce) exists in new born
.AT is also effective by Trec
.Trec（T-cell receptor excision circles）:in Thymus recontruction T cell Receptor in 48 ours. This circle induces from part of genome DNA
,cutting from that.
.Trec screening is very wonderfull but costs high
2-高-10
.hepatoblastoma
mutation of CTNNB1(EXON3 in neonatal periodd?) is one cause. That function inhibited.
.New generation sequence is better than ex. SANGER method.
3-高-11
glucocorticoid receptor GR SNIP Bc/l GR-0betha N363S,R23K
result Bc/l is problem in G/G?
premature ; low responder SNIP(Bc/l) enstronge that tendency.
cortizol admi
nistration is curable?
3-高-12 SHFM SHFLD
BHLH9 gene abnormal mutation of duplication, triplication 100%
TUSC5 is not associated
japanese ancient mutation is most thoughtable.