gomari03-02004302210@
The ADCC capacity of macrophages from C3H/HeJ and A/J mice can be augmented by BCG.
Koren HS, Meltzer MS, Adams DO.
Abstract
Macrophages elicited from the peritoneal cavity of C3H/HejJ and A/J mice by bacillus Calmette-Guérin (BCG), although ineffective in mediating tumor cytotoxicity, had augmented capacity to mediate antibody-dependent cellular cytotoxicity (ADCC) against both erythroid and neoplastic target cells. The level of augmented ADCC was comparable to that expressed by BCG-activated macrophages from control C3H/HeN mice. The data suggest that the defective potential for cytolytic activation in 2 genetically deficient strains of inbred mice does not extend to augmentation of capacity for mediating ADCC and that full expression of cytolytic activation is not necessary for expression of augmented cytolysis of antibody-coated targets.
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
Ivy Widjaja, Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvare
実験系：ガンの発症率の高い近交系としてC3H系が作出されました。その後Hestonに渡り維持されていた亜系C3H/Heを、ジャクソン研究所が導入してC3H/HeJとなりエンドトキシンに対しては、C3H/HeJは抵抗性<->C3H/HeNは感受性
J Immunol. 1981 Mar;126(3):1013-5.